Make hair grow new discover
PC Luis Quiroz Ravines
Make hair grow- Alopecia or baldness is the loss of hair associated with a series of factors such as stress, hormonal imbalance, treatment with chemotherapy, aging and other causes.
Millions of men and women in the world are constantly looking ways make hair grow. Only in the United States, more than 50 million people suffer from hair loss and the news that follows can be a new hope for them.
Research led by scientists Heather Christofk and William Lowry of the University of California (UCLA) have discovered a different way to activate stem cells in the hair follicle to grow hair.
This new discovery could encourage the creation of new products or drugs to stimulate and grow the hair of millions of men and women with thinning hair or hair loss that can end in a pronounced baldness.
The journal Nature Cell Biology published the findings of the investigations of Heather Christofk and William Lowry.
Throughout the existence of a person, hair follicle stem cells, which are long-lived skin cells, produce hair and are usually inactive but during a new hair growth cycle are activated quickly and that is when It causes new hair growth.
Many factors regulate the “inactivity” of hair follicle stem cells and when in some cases, they do not really activate, hair loss occurs.
Make hair grow new opportunity
At Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at UCLA, researchers Christofk and Lowry discovered that the metabolism of hair follicle stem cells is different from other skin cells.
The decomposition of nutrients is necessary for the cells to divide, this cellular metabolism implies the generation of energy and its response to its environment. Nutrients are altered by the process of metabolism that use enzymes to produce “metabolites”
A glucose nutrient is a form of sugar and as the mother cells consume this glucose from the bloodstream, they process the glucose to produce in the end a metabolite called “pyruvate”
From here the cells can send pyruvate to their mitochondria, that is, to the part of the cell that generates energy, or alternatively, they can transform pyruvate into a new metabolite called lactate.
The researchers, after observing the metabolism of the hair follicle stem cells, considered examining whether, by genetically diminishing the entry of pyruvate into the mitochondria, it would force the hair follicle stem cells to produce more lactate and if this increased production of lactate would activate The cells and hair would grow faster, said Heather Christofk, associate professor of biological chemistry and molecular and medical pharmacology.
The researchers first tested on mice that genetically blocked lactate production and this blockade showed that this prevented the activation of hair follicle stem cells.
In opposition to this lactate restriction and in collaboration with the Rutter laboratory of the University of Utah, the lactate production was significantly increased genetically in the test mice and the result was acceleration, of the activity of the hair follicle stem cells and consequently increase the cycle to make hair grow .
Lowry, a professor of molecular, cellular and developmental biology, said that before this experience nobody knew that the increase or decrease of lactate would have an effect on hair follicle stem cells.
Having verified this alteration of lactate production in mice that influenced hair growth, the scientists looked for appropriate drugs that, applied to the skin, had the same results.
Two drugs were located by the researchers, which when applied to the skin of the mice, influenced the hair follicle stem cells and in different ways promoted lactate production.
A first drug identified as RCGD423 activates a cellular signaling pathway called JAK-Stat, which transmits information from the outside of the cell to the nucleus of the cell.
It was discovered that the activation of JAK-Stat causes a higher production of lactate and this higher production stimulates the activation of hair follicle stem cells and consequently faster hair growth.
The second drug called UK5099, prevents or blocks the entry of pyruvate into the mitochondria, which forces a higher production of lactate in the hair follicle stem cells and accelerates hair growth in mice.
Aimee Flores, a predoctoral trainee in Lowry’s lab, said “Through this study, we got a lot of important information about new ways to activate stem cells”
Aimee Flores is a predoctoral apprentice in Lowry’s laboratory and first author of the study.
The possibility of using medications to stimulate hair growth using hair follicle stem cells is a very encouraging discovery for millions of people, men, and women who suffer from alopecia or baldness, thinning hair or incipient hair loss.
Researchers believe that the fundamental role of metabolism in hair growth and the role of stem cells in the hair follicle has just begun to be understood.
The rapid application of these discoveries and the placement of the indicated drugs can bring hope to men and women who are looking for how to grow hair.
The RCGD423 and UK5099 drugs for hair growth are protected by provisional patents filed by
UCLA Technology Development Group on behalf of UC Regents and UC R
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